Phylodynamic of SARS-CoV-2 during the second wave of COVID-19 in Peru

Autor(es)

Justo Arevalo, Santiago ; Uribe Calampa, Carmen Sofia ; Jimenez Silva, Cinthy ; Quinones Aguilar, Mauro ; Bouckaert, Remco ; Rebello Pinho, Joao Renato

• Tipo de documento: Artigo Científico
• Fonte: NATURE COMMUNICATIONS; v. 14, n. 1, p. 13-pg., 2023-06-15.

Resumo

At over 0.6% of the population, Peru has one of the highest SARS-CoV-2 mortality rate in the world. Much effort to sequence genomes has been done in this country since mid-2020. However, an adequate analysis of the dynamics of the variants of concern and interest (VOCIs) is missing. We investigated the dynamics of the COVID-19 pandemic in Peru with a focus on the second wave, which had the greatest case fatality rate. The second wave in Peru was dominated by Lambda and Gamma. Analysis of the origin of Lambda shows that it most likely emerged in Peru before the second wave (June-November, 2020). After its emergence it reached Argentina and Chile from Peru where it was locally transmitted. During the second wave in Peru, we identify the coexistence of two Lambda and three Gamma sublineages. Lambda sublineages emerged in the center of Peru whereas the Gamma sublineages more likely originated in the north-east and mid-east. Importantly, it is observed that the center of Peru played a prominent role in transmitting SARS-CoV-2 to other regions within Peru. (AU)

• Processo FAPESP: 15/13318-4 - Engenharia estrutural do sítio ativo de diguanilato ciclases (domínios GGDEF) para a produção de novos segundos mensageiros
• Beneficiário: Santiago Justo Arevalo
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 22/00943-1 - Estudos estruturais e funcionais na enzima degradadora de cianeto CynD de Bacillus safensis PER-URP-08
• Beneficiário: Santiago Justo Arevalo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado