| Texto completo | |
| Autor(es): |
Ferreira, Laura Teofilo
;
Mannochio-Russo, Helena
;
Isquibola, Guilherme
;
Fernandes, Richard Perosa
;
de Mourac, Aniele
;
Bolzani, Vanderlan da Silva
;
Caires, Flavio Junior
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS; v. 173, p. 9-pg., 2023-06-17. |
| Resumo | |
Candesartan is a widely used active pharmaceutical ingredient in the treatment of systemic arterial hypertension. This work presents the investigation of the thermal behavior of candesartan, such as its thermal stability, melting temperature, and thermal decomposition, both in pyrolysis (N2) or oxidizing (air) conditions by evolved gas analysis (EGA). The thermal study showed that the drug melts at 189 degrees C (onset at 184 degrees C) followed by decomposition in six mass loss steps. The drug presents a similar thermal behavior under pyrolytic and oxidizing conditions up to 360 degrees C. The main gaseous products released are N2O, NH3, CO, CO2, HCN, and CH3CH2NCO (ethyl isocyanate). Pyrolysis degradation products have been analyzed, and a thermal degradation pathway has been proposed with fifteen different structures based on the HRMS and MS/MS analysis. Furthermore, the characterization of the pyrolytic degradation products of candesartan by UHPLC-HRMS is reported for the first time, showing that the initial degradation pathway occurs through a dimerization reaction. (AU) | |
| Processo FAPESP: | 18/24378-6 - Síntese, caracterização e estudo termoanalítico de cocristais de Valsartana, Candesartana Cilexetila e Olmesartana medoxomila |
| Beneficiário: | Flávio Junior Caires |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos |
| Beneficiário: | Glaucius Oliva |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 14/50926-0 - INCT 2014: biodiversidade e produtos naturais |
| Beneficiário: | Vanderlan da Silva Bolzani |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |