| Texto completo | |
| Autor(es): Mostrar menos - |
Khan, Muzamil Majid
;
Lustrino, Danilo
;
Silveira, Willian A.
;
Wild, Franziska
;
Straka, Tatjana
;
Issop, Yasmin
;
O'Connor, Emily
;
Cox, Dan
;
Reischl, Markus
;
Marquardt, Till
;
Labeit, Dittmar
;
Labeit, Siegfried
;
Benoit, Evelyne
;
Molgo, Jordi
;
Lochmueller, Hanns
;
Witzemann, Veit
;
Kettelhut, Isis C.
;
Navegantes, Luiz C. C.
;
Pozzan, Tullio
;
Rudolf, Ruediger
Número total de Autores: 20
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; v. 113, n. 3, p. 5-pg., 2016-01-19. |
| Resumo | |
The distribution and function of sympathetic innervation in skeletal muscle have largely remained elusive. Here we demonstrate that sympathetic neurons make close contact with neuromuscular junctions and form a network in skeletal muscle that may functionally couple different targets including blood vessels, motor neurons, and muscle fibers. Direct stimulation of sympathetic neurons led to activation of muscle postsynaptic beta 2-adrenoreceptor (ADRB2), cAMP production, and import of the transcriptional coactivator peroxisome proliferator-activated receptor gamma-coactivator 1 alpha (PPARGC1A) into myonuclei. Electrophysiological and morphological deficits of neuromuscular junctions upon sympathectomy and in myasthenic mice were rescued by sympathicomimetic treatment. In conclusion, this study identifies the neuromuscular junction as a target of the sympathetic nervous system and shows that sympathetic input is crucial for synapse maintenance and function. (AU) | |
| Processo FAPESP: | 12/24524-6 - Controle da massa muscular pela via de sinalização do AMPc |
| Beneficiário: | Isis Do Carmo Kettelhut |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 10/11083-6 - Papel da epac no controle do metabolismo protéico em músculos esqueléticos |
| Beneficiário: | Wilian de Assis Silveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 12/05697-7 - Interação funcional entre o sistema colinérgico e adrenérgico na manutenção da massa muscular e da placa motora |
| Beneficiário: | Danilo Lustrino Borges |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 12/51456-1 - Role and mechanism of action of anabolic stimuli on neuromuscular trophicity |
| Beneficiário: | Isis Do Carmo Kettelhut |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |