Sex determination and Aedes population control

Autor(es)

Correa de Araujo, Helena Rocha ; Kojin, Bianca Burini ; Capurro, Margareth Lara

• Tipo de documento: Artigo Científico
• Fonte: PARASITES & VECTORS; v. 11, p. 7-pg., 2018-12-24.

Resumo

The global economic cost of Aedes-borne diseases, such as dengue, is estimated to be in the billions of dollars annually. In this scenario, a sustained vector control strategy is the only alternative to control dengue, as well as other diseases transmitted by Aedes, including Zika and chikungunya. The use of transgenic mosquitoes is a promising weapon in the improvement of approaches currently applied in Aedes aegypti control. Field trials using genetically modified mosquitoes for population control have been conducted and offer an excellent opportunity to evaluate what can be improved. In a mass-rearing mosquito facility, the absence of a transgenic line that produces male-only progeny is undoubtedly a limiting factor; thus, being able to manipulate sex determination in this species is a fundamental step for the success of this strategy. Likewise, the possibility of manipulation of the sex determination pathway opens-up a new opportunity for disease control. (AU)

• Processo FAPESP: 13/16609-4 - Conversão do sexo do Aedes aegypti por transgenia
• Beneficiário: Helena Corrêa de Araújo Gomes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado