| Texto completo | |
| Autor(es): |
Pillat, Micheli Mainardi
;
Oliveira-Giacomelli, Agatha
;
das Neves Oliveira, Mona
;
Andrejew, Roberta
;
Turrini, Natalia
;
Baranova, Juliana
;
Lah Turnsek, Tamara
;
Ulrich, Henning
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Cytometry Part A; v. 99, n. 2, p. 12-pg., 2021-01-13. |
| Resumo | |
Glioblastoma (GBM) is one of the most malignant and devastating brain tumors. The presence of highly therapy-resistant GBM cell subpopulations within the tumor mass, rapid invasion into brain tissues and reciprocal interactions with stromal cells in the tumor microenvironment contributes to an inevitable fatal prognosis for the patients. We highlight the most recent evidence of GBM cell crosstalk with mesenchymal stem cells (MSCs), which occurs either by direct cell-cell interactions via gap junctions and microtubules or cell fusion. MSCs and GBM paracrine interactions are commonly observed and involve cytokine signaling, regulating MSC tropism toward GBM, their intra-tumoral distribution, and immune system responses. MSC-promoted effects depending on their cytokine and receptor expression patterns are considered critical for GBM progression. MSC origin, tumor heterogeneity and plasticity may also determine the outcome of such interactions. Kinins and kinin-B1 and -B2 receptors play important roles in information flow between MSCs and GBM cells. Kinin-B1 receptor activity favors tumor migration and fusion of MSCs and GBM cells. Flow and image (tissue) cytometry are powerful tools to investigate GBM cell and MSC crosstalk and are applied to analyze and characterize several other cancer types. (AU) | |
| Processo FAPESP: | 12/50880-4 - Células-tronco: dos papéis de receptores de cininas e purinas às aplicações terapêuticas |
| Beneficiário: | Alexander Henning Ulrich |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/10725-6 - Avaliação dos receptores de purinérgicos na comorbidade do transtorno bipolar e da Doença de Alzheimer |
| Beneficiário: | Natalia Turrini |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 19/24553-5 - O papel do receptor P2Y1 na Doença de Parkinson |
| Beneficiário: | Roberta Andrejew Caetano |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 19/26852-0 - Estudo do antagonismo de receptores purinérgicos no processo inflamatório e ativação microglial em modelos in vivo e in vitro de Doença de Parkinson |
| Beneficiário: | Ágatha Oliveira Giacomelli |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas |
| Beneficiário: | Alexander Henning Ulrich |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |