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| Autor(es): Mostrar menos - |
Zanette, Dalila Luciola
;
Coelho, Karoline Brito Caetano Andrade
;
de Carvalho, Eneas
;
Aoki, Mateus Nobrega
;
Nardin, Jeanine Marie
;
Lalli, Larissa Araujo
;
Bezerra, Rafael dos Santos
;
Giovanetti, Marta
;
Zucherato, Victoria Simionatto
;
de Campos, Gabriel Montenegro
;
Bernardino, Jardelina de Souza Todao
;
Viala, Vincent Louis
;
Ciccozzi, Massimo
;
Alcantara, Luiz Carlos Junior
;
Sampaio, Sandra Coccuzzo
;
Elias, Maria Carolina
;
Kashima, Simone
;
Covas, Dimas Tadeu
;
Slavov, Svetoslav Nanev
Número total de Autores: 19
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| Tipo de documento: | Artigo Científico |
| Fonte: | MOLECULAR & CELLULAR ONCOLOGY; v. 10, n. 1, p. 9-pg., 2023-12-31. |
| Resumo | |
Growing evidence suggests that metavirome changes could be associated increased risk for malignant cell transformation. Considering Viruses have been proposed as factors for prostate cancer induction. The objective of this study was to examine the composition of the plasma metavirome of patients with prostate cancer. Blood samples were obtained from 49 male patients with primary prostate adenocarcinoma. Thirty blood donors were included as a control group. The obtained next-generation sequencing data were analyzed using a bioinformatic pipeline for virus metagenomics. Viral reads with higher abundance were assembled in contigs and analyzed taxonomically. Viral agents of interest were also confirmed by qPCR. Anelloviruses and the Human Pegivirus-1 (HPgV-1) were the most abundant component of plasma metavirome. Clinically important viruses like hepatitis C virus (HCV), cytomegalovirus and human adenovirus type C were also identified. In comparison, the blood donor virome was exclusively composed of torque teno virus types (TTV) types. The performed HPgV-1 and HCV phylogeny revealed that these viruses belong to commonly detected in Brazil genotypes. Our study sheds light on the plasma viral abundance in patients with prostatic cancer. The obtained viral diversity allowed us to separate the patients and controls, probably suggesting that malignant processes may influence virome composition. More complex and multiple approach investigations are necessary to examine the likely causal relationship between metavirome and its nvolvement in prostate cancer. (AU) | |
| Processo FAPESP: | 19/08528-0 - Aplicação de métodos de bioinformática para identificação de infecções virais com impacto em hemoterapia |
| Beneficiário: | Rafael dos Santos Bezerra |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 22/00910-6 - Desenvolvimento e aplicação de pipelines de bioinformática para análise metagenômica viral em amostras clínicas |
| Beneficiário: | Gabriel Montenegro de Campos |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 17/23205-8 - Avaliação do impacto de vírus emergentes e re-emergentes em hemoterapia e transplante de células-tronco por meio de técnicas moleculares avançadas |
| Beneficiário: | Svetoslav Nanev Slavov |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 20/13194-1 - Avaliação molecular da prevalência e aplicação de métodos de sequenciamento de última geração para identificação de vírus emergentes na área de hemoterapia |
| Beneficiário: | Victória Simionatto Zucherato |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |