| Texto completo | |
| Autor(es): |
dos Reis, Larissa Menezes
;
Bercot, Marcelo Rodrigues
;
Castelucci, Bianca Gazieri
;
Martins, Ana Julia Estumano
;
Castro, Gisele
;
Moraes-Vieira, Pedro M. M.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Viruses-Basel; v. 15, n. 2, p. 32-pg., 2023-02-01. |
| Resumo | |
RNA viruses are known to induce a wide variety of respiratory tract illnesses, from simple colds to the latest coronavirus pandemic, causing effects on public health and the economy worldwide. Influenza virus (IV), parainfluenza virus (PIV), metapneumovirus (MPV), respiratory syncytial virus (RSV), rhinovirus (RhV), and coronavirus (CoV) are some of the most notable RNA viruses. Despite efforts, due to the high mutation rate, there are still no effective and scalable treatments that accompany the rapid emergence of new diseases associated with respiratory RNA viruses. Host-directed therapies have been applied to combat RNA virus infections by interfering with host cell factors that enhance the ability of immune cells to respond against those pathogens. The reprogramming of immune cell metabolism has recently emerged as a central mechanism in orchestrated immunity against respiratory viruses. Therefore, understanding the metabolic signature of immune cells during virus infection may be a promising tool for developing host-directed therapies. In this review, we revisit recent findings on the immunometabolic modulation in response to infection and discuss how these metabolic pathways may be used as targets for new therapies to combat illnesses caused by respiratory RNA viruses. (AU) | |
| Processo FAPESP: | 20/09535-8 - A modulação da dinâmica mitocondrial como ferramenta para a repolarização de macrófagos no tratamento do câncer |
| Beneficiário: | Larissa Menezes dos Reis |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/25973-8 - Mitoimunidade: estudo da adaptação da mitocôndria em estados fisiológicos e patológicos |
| Beneficiário: | Pedro Manoel Mendes de Moraes Vieira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/16030-0 - Adaptação imunometabólica de macrófagos teciduais residentes na saúde e na doença |
| Beneficiário: | Pedro Manoel Mendes de Moraes Vieira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 21/01147-1 - Estudo da influência do metabolismo da arginina no perfil imunometabólico de macrófagos |
| Beneficiário: | Ana Julia Estumano Martins |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |