| Texto completo | |
| Autor(es): |
Damiano, Rodolfo Furlan
;
Loureiro, Julia Cunha
;
Pais, Marcos Vasconcelos
;
Pereira, Rodrigo Furtado
;
Corradi, Marina de Menezes
;
Di Santi, Talita
;
Bezerra, Gustavo Antonio Marcolongo
;
Radanovic, Marcia
;
Talib, Leda Leme
;
Forlenza, Orestes Vicente
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Revista Brasileira de Psiquiatria; v. 45, n. 1, p. 4-pg., 2023-01-01. |
| Resumo | |
Objectives: To re-evaluate a sample of older adults enrolled in a randomized controlled trial of lithium for amnestic mild cognitive impairment (MCI) after 11 to 15 years, re-assessing their current (or last available) global cognitive and functional state.Methods: We recalled all former participants of the Lithium-MCI trial conducted by our group between 2009 and 2012 to perform a single-blinded, cross-sectional evaluation of their global clinical state to compare the long-term outcome of those who received lithium vs. those who received placebo.Results: Of the original sample (n=61), we were able to reach 36 participants (59% of retention), of whom 22 had previously received lithium (61% of the recall sample) and 14 (39%) had received placebo. Since 30.5% of the recalled sample was deceased, psychometric data were collected only for 69.5% of the participants. We found statistically significant differences in current mean Mini Mental State Examination score according to previous treatment group (25.5 [SD, 5.3] vs. 18.3 [SD, 10.9], p = 0.04). The lithium group also had better performance in the phonemic Verbal Fluency Test than the control group (34.4 [SD, 14.4] vs. 11.6 [SD, 10.10], p o 0.001). Differences in these measures also had large effect sizes, as shown by Cohen's d values of 0.92 and 1.78, respectively.Conclusion: This data set suggests that older adults with amnestic MCI who had been treated with lithium during a previous randomized controlled trial had a better long-term global cognitive outcome than those from a matched sample who did not receive the intervention. (AU) | |
| Processo FAPESP: | 19/08507-3 - Efeitos neuroprotetores do lítio em indivíduos com risco de acometimento pela Doença de Alzheimer |
| Beneficiário: | Orestes Vicente Forlenza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/50873-3 - INCT 2014: Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN) |
| Beneficiário: | Wagner Farid Gattaz |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |