Sodium Salicylate as Feed Additive in Broilers: Absence of Toxicopathological Findings

Autor(es)

Di Gregorio, Mayra Carraro ; de Almeida, Elaine Renata Motta ; Momo, Claudia ; Araujo, Cristiane Soares da Silva ; Hueza, Isis Machado ; Andreo-Filho, Newton ; Raspantini, Leonila Ester Reinert ; Gotardo, Andre Tadeu ; Gorniak, Silvana Lima

• Tipo de documento: Artigo Científico
• Fonte: ANIMALS; v. 13, n. 9, p. 13-pg., 2023-04-22.

Resumo

Antimicrobial growth promoters (AGPs) in animal production have been related to the increase in multidrug-resistant bacteria. The AGP ban in many countries has highlighted the growing need for alternatives for feed additives. Considering the non-antibiotic anti-inflammatory theory of AGPs, chicks received three different doses of sodium salicylate (SS) in feed (10, 30, 90 mg/kg), basal diet (BD) was used as a negative control, and zinc bacitracin (ZB) was used as a positive control. Chicks were individually housed to increase the accuracy of the dose of SS ingested. Performance parameters and footpad dermatitis were evaluated weekly, while haematology, serum biochemistry, histopathology, and tibial dyschondroplasia were determined on Days 21 and 42. A linear dose-dependent decrease in haemoglobin concentration was observed, but the values were within the normal reference range. Among all the other evaluated parameters, no relevant differences between treatments were observed; however, not even the AGP group performed better than the control group. It is possible that the conditions in which the birds were raised were not stressful enough to allow for anti-inflammatories to demonstrate their beneficial effects on performance. Studies should be conducted where the animals are exposed to commercial conditions, as the presence of natural stressors could allow a better evaluation of the efficacy of the anti-inflammatory agent as a growth promoter. (AU)

• Processo FAPESP: 19/07151-0 - Adição de anti-inflamatórios não esteroidais na dieta de frangos de corte como alternativa ao uso de antimicrobianos melhoradores de desempenho
• Beneficiário: Mayra Carraro Di Gregorio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/19474-6 - Uso de anti-inflamatório associado ao probiótico: uma provável alternativa ao emprego de antimicrobianos como melhoradores de desempenho: estudo em frangos de corte
• Beneficiário: Silvana Lima Gorniak
• Modalidade de apoio: Auxílio à Pesquisa - Regular