Cytotoxic Guanidine Alkaloids from Pterogyne nitens

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Regasini, Luis Octavio ; Castro-Gamboa, Ian ; Siqueira Silva, Dulce Helena ; Furlan, Maysa ; Barreiro, Eliezer Jesus ; Pinheiro Ferreira, Paulo Michel ; Pessoa, Claudia ; Costa Lotufo, Leticia Veras ; de Moraes, Manoel Odorico ; Marx Young, Maria Claudia ; Bolzani, Vanderlan da Silva

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 72, n. 3, p. 4-pg., 2009-03-01.

Resumo

As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of I and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells. (AU)

• Processo FAPESP: 03/02176-7 - Conservação e uso sustentável da diversidade do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais - fase II
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático