| Texto completo | |
| Autor(es): |
Bosquesi, Priscila Longhin
;
Ferreira Melo, Thais Regina
;
Vizioli, Ednir Oliveira
;
dos Santos, Jean Leandro
;
Chung, Man Chin
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACEUTICALS; v. 4, n. 11, p. 25-pg., 2011-11-01. |
| Resumo | |
The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer's disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach. (AU) | |
| Processo FAPESP: | 10/12495-6 - Otimização, síntese e avaliação farmacológica de novos candidatos a fármacos para tratamento dos sintomas da anemia falciforme |
| Beneficiário: | Jean Leandro dos Santos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 10/50330-9 - Planejamento, síntese e avalição biológica de derivados furoxânicos e benzofuroxanicos potencialmente antichagásicos |
| Beneficiário: | Priscila Longhin Bosquesi |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |