Ethanol-Induced Memory Impairment in a Discriminative Avoidance Task is State-Dependent

Autor(es)

Sanday, Leandro ; Patti, Camilla L. ; Zanin, Karina A. ; Fernandes-Santos, Luciano ; Oliveira, Larissa C. ; Kameda, Sonia R. ; Tufik, Sergio ; Frussa-Filho, Roberto

• Tipo de documento: Artigo Científico
• Fonte: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH; v. 37, p. 10-pg., 2013-01-01.

Resumo

Background A considerable amount of experimental evidence has demonstrated ethanol (EtOH) induced amnestic effects following EtOH administration during pretraining in a variety of tasks both in humans and in laboratory animals. Although the phenomenon of state-dependency is known to play a critical role in memory deficits induced by both pharmacological and nonpharmacological pretraining perturbations, the involvement of this phenomenon in EtOH-induced anterograde amnesia has been overlooked. This study aimed to investigate the role of state-dependency in EtOH-induced amnestic effects and its interactions with the well-known anxiolysis and locomotor alterations. Methods Mice were treated with 1.2 or 2.4 g/kg EtOH before training and/or before testing in the plus-maze discriminative avoidance task, an animal model that concomitantly evaluates learning, memory, anxiety-like behavior, and general activity. Results Whereas both doses of EtOH induced anxiolysis, the 1.2 g/kg dose enhanced locomotion while the 2.4 g/kg dose decreased it. In addition, the administration of 1.2 g/kg of this drug during pretraining caused memory impairment, which was counteracted by the pretest administration of the same dose, revealing the participation of the state-dependency. Conversely, the administration of 2.4 g/kg EtOH led to amnestic effects irrespective of the time of the administration (pretraining and/or pretest), eliminating the influence of state-dependency. Conclusions Our data demonstrate that EtOH-induced memory deficits are critically related to state-dependency, which can also be affected by the dose range. These results indicate the possible participation of EtOH-induced modifications in anxiety and motor activity levels in relation to state-dependent memory deficits. (AU)

• Processo FAPESP: 08/08823-8 - Efeitos do zolpidem sobre o aprendizado e a memória de camundongos avaliados no modelo da esquiva discriminativa em labirinto em cruz elevado
• Beneficiário: Karina Agustini Zanin
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 04/14606-9 - Manipulações experimentais dos efeitos amnésticos promovidos pela privação de sono em camundongos: uma abordagem comportamental
• Beneficiário: Camilla de Lima Patti Hissamura
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto