Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System

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Rodrigues, Bruno ; Santana, Aline Alves ; Santamarina, Aline Boveto ; Oyama, Lila Missae ; Caperuto, Erico Chagas ; de Souza, Claudio Teodoro ; Barboza, Catarina de Andrade ; Rocha, Leandro Yanase ; Figueroa, Diego ; Mostarda, Cristiano ; Irigoyen, Maria Claudia ; Lira, Fabio Santos

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; v. 2014, p. 13-pg., 2014-01-01.

Resumo

The aim of this study was to evaluate the effects of exercise training (ET, 50-70% of VO2max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n = 10; 3 months of ET), and detrained infarcted (DI, n = 11; 2 months of ET + 1 month of DT). After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue. These positive changes were sustained even after 1 month of detraining. No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups. In conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI. These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI. (AU)

• Processo FAPESP: 07/58942-0 - Da bancada à clínica: desenvolvimento de biomarcadores como preditores da resposta à terapêutica e lesão de órgãos-alvo na hipertensão arterial sistemática
• Beneficiário: Eduardo Moacyr Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/14788-9 - Efeitos do treinamento físico associado à estimulação colinérgica por brometo de piridostigmina previamente e após o infarto do miocárdio: papel na função cardíaca, autonômica e no perfil inflamatório
• Beneficiário: Bruno Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Regular