The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases

Autor(es)

Ferreira, Caroline Marcantonio ; Vieira, Angelica Thomaz ; Ramirez Vinolo, Marco Aurelio ; Oliveira, Fernando A. ; Curi, Rui ; Martins, Flaviano dos Santos

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2014, p. 12-pg., 2014-01-01.

Resumo

The commensal microbiota is in constant interaction with the immune system, teaching immune cells to respond to antigens. Studies in mice have demonstrated that manipulation of the intestinal microbiota alters host immune cell homeostasis. Additionally, metagenomic-sequencing analysis has revealed alterations in intestinal microbiota in patients suffering from inflammatory bowel disease, asthma, and obesity. Perturbations in the microbiota composition result in a deficient immune response and impaired tolerance to commensal microorganisms. Due to altered microbiota composition which is associated to some inflammatory diseases, several strategies, such as the administration of probiotics, diet, and antibiotic usage, have been utilized to prevent or ameliorate chronic inflammatory diseases. The purpose of this review is to present and discuss recent evidence showing that the gut microbiota controls immune system function and onset, development, and resolution of some common inflammatory diseases. (AU)

• Processo FAPESP: 12/50410-8 - Efeito dos ácidos graxos de cadeia curta produzidos por bactérias probióticas na profilaxia e tratamento da inflamação alérgica das vias aéreas
• Beneficiário: Caroline Marcantonio Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/10653-9 - Envolvimento dos ácidos graxos de cadeia curta e seu receptor (GPR43) na resposta imune a bactérias anaeróbias in vivo e in vitro
• Beneficiário: Marco Aurélio Ramirez Vinolo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/50336-2 - Interação entre hipometabolismo, dinâmica do cálcio e excitabilidade neuronal: implicações no processo degenerativo da doença de Alzheimer
• Beneficiário: Fernando Augusto de Oliveira Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores