| Texto completo | |
| Autor(es): |
Campo, Vanessa L.
;
Ivanova, Irina M.
;
Carvalho, Ivone
;
Lopes, Carla D.
;
Carneiro, Zumira A.
;
Saalbach, Gerhard
;
Schenkman, Sergio
;
da Silva, Joao Santana
;
Nepogodiev, Sergey A.
;
Field, Robert A.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Tetrahedron; v. 71, n. 39, p. 10-pg., 2015-09-30. |
| Resumo | |
Reaction of 2-(2-(2-azidoethoxy)ethoxy)ethyl 6-O-(prop-2-ynyl)-beta-D-galactopyranoside (7) under CuAAC conditions gives rise to mixed cyclic and linear triazole-linked oligomers, with individual compounds up to d.p. 5 isolable, along with mixed larger oligomers. The linear compounds resolve en bloc from the cyclic materials by RP HPLC, but are separable by gel permeation chromatography. The triazole-linked oligomers pseudo-galactooligomers were demonstrated to be acceptor substrates for the multi-copy cell surface trans-sialidase of the human parasite Trypanosoma cruzi. In addition, these multivalent TcTS ligands were able to block macrophage invasion by T. cruzi. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license. (AU) | |
| Processo FAPESP: | 12/19390-0 - Desenvolvimento de glicoconjugados de mucinas com aplicações diagnósticas e terapêuticas em distrofias musculares e câncer |
| Beneficiário: | Vanessa Leiria Campo |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |