Emerging targets for combination therapy in melanomas

Autor(es)

Saito, Renata de Freitas ; Tortelli, Tharcisio Citrangulo, Jr. ; Jacomassi, Mayara D'Auria ; Otake, Andreia Hanada ; Chammas, Roger

• Tipo de documento: Artigo Científico
• Fonte: FEBS Letters; v. 589, n. 22, p. 11-pg., 2015-11-14.

Resumo

Cutaneous melanomas are often difficult to treat when diagnosed in advanced stages. Melanoma cells adapt to survive in extreme environmental conditions and are among the tumors with larger genomic instability. Here we discuss some intrinsic and extrinsic mechanisms of resistance of melanoma cells to both conventional and target therapies, such as autophagy, adaptation to endoplasmic reticulum stress, metabolic reprogramming, mechanisms of tumor repopulation and the role of extracellular vesicles in this later phenomenon. These biological processes are potentially targetable and thus provide a platform for research and discovery of new drugs for combination therapy to manage melanoma patient treatment. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/06120-8 - Aumento transitório da perfusão tumoral como estratégia de melhora da distribuição de moléculas com potencial terapêutico em modelo experimental de melanoma
• Beneficiário: Roger Chammas
• Modalidade de apoio: Auxílio à Pesquisa - Regular