Palladium(II)/N,N-disubstituted-N '-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents

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Plutin, Ana M. ; Alvarez, Anislay ; Mocelo, Raul ; Ramos, Raul ; Castellano, Eduardo E. ; da Silva, Monize M. ; Villarreal, Wilmer ; Pavan, Fernando R. ; Meira, Cassio Santana ; Rodrigues Filho, Jose Simao ; Moreira, Diogo Rodrigo M. ; Soares, Milena Botelho P. ; Batista, Alzir A.

• Tipo de documento: Artigo Científico
• Fonte: Polyhedron; v. 132, p. 8-pg., 2017-08-16.

Resumo

The new complexes of Pd(II) with N,N-disubstituted-N'-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N'benzoylthioureato-k(2)O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N'-benzoylthioureato-k(2)O,S)]PF6, (3) [Pd(dppf) (N,N-dibuthyl-N'-benzoylthioureato-k(2)O,S)]PE6, (4) [Pd(dPPO(N,N-diphenyl-N'-benzoylthioureato-k(2)O, S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N'-furoylthioureato-k(2)O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N'-furoylthioureato-k(2)O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N'-thiophenylthioureato-k(2)O,S)]PF6, and (8) [Pd(dppf) (N,N-diphenyl-N'-thiophenylthioureato-k(2)O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The. results demonstrated that the compounds described here can be considered as promising anti Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 14/13691-4 - A cristalografia como ferramenta no auxílio para a elucidação do mecanismo de ação de potenciais metalofármacos
• Beneficiário: Eduardo Ernesto Castellano
• Modalidade de apoio: Auxílio à Pesquisa - Regular