| Texto completo | |
| Autor(es): Mostrar menos - |
dos Santos, Klinsmann Carolo
;
Bueno, Bianca Guerra
;
Pereira, Luana Ferreira
;
Francisqueti, Fabiane Valentini
;
Braz, Mariana Gobbo
;
Bincoleto, Lahis Fernandes
;
da Silva, Lilian Xavier
;
Ferreira, Ana Lucia A.
;
de Melo Stevanato Nakamune, Ana Claudia
;
Chen, C. -Y. Oliver
;
Blumberg, Jeffrey B.
;
Correa, Camila Renata
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Evidence-based Complementary and Alternative Medicine; v. 2017, p. 9-pg., 2017-01-01. |
| Resumo | |
Theeffects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats. (AU) | |
| Processo FAPESP: | 15/10626-0 - Inter-relação do gama-orizanol e ativação dos receptores Adipo- R1 e Adipo- R2: possível efeito na melhora da função renal associada à obesidade |
| Beneficiário: | Camila Renata Corrêa |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/17364-8 - Efeito do extrato das folhas da Smallanthus sonchifolius (yacon) sobre as alterações metabólicas no músculo esquelético de ratos com Diabetes mellitus experimental |
| Beneficiário: | Bianca Guerra Bueno |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |