| Texto completo | |
| Autor(es): |
Auras, Bruna L.
;
Meller, Sheila De Lucca
;
Da Silva, Marcos Paulo
;
Neves, Ademir
;
Cocca, Leandro H. Z.
;
De Boni, Leonardo
;
da Silveira, Carolina Hahn
;
Iglesias, Bernardo A.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | APPLIED ORGANOMETALLIC CHEMISTRY; v. 32, n. 5, p. 12-pg., 2018-05-01. |
| Resumo | |
We report the synthesis and characterization of two new meso-ferrocenylporphyrins, with the ferrocenyl unit attached at the para position of a C6F4 group by a C-N bond with -NH(CH2)(2)NH- (2a) and -NH(CH2)(4)NH- (2b) spacers. Compounds 2a and 2b were characterized through elemental analyses, electrospray ionization high-resolution mass spectrometry, H-1 NMR, UV-visible and fluorescence spectroscopies, electrochemistry and spectroelectrochemistry. The free base porphyrin 2 was included for comparison purposes. The binding ability of 2 and the porphyrin derivatives 2a and 2b with calf thymus DNA was determined using U V-visible and fluorescence spectroscopies. The results suggest that the interaction of these systems most probably occurs through pi-stacking by non-classical modes involving the partial insertion of the C6F5 ring between adjacent base pairs on DNA and possible hydrogen interaction with the aliphatic -NH(CH2)(n)NH- (n = 2 or 4) groups with calf thymus DNA. Moreover, we also demonstrate that porphyrins generate singlet oxygen species and show good photostability after irradiation. (AU) | |
| Processo FAPESP: | 16/20886-1 - Modernização da linha de Espectroscopia Óptica Não Linear ultrarrápida: Absorção transiente e chave kerr óptica com controle da polarização. |
| Beneficiário: | Leonardo de Boni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |