Influence of aversive stimulation on haloperidol-induced catalepsy in rats

Autor(es)

Barroca, Nayara C. B. ; Guarda, Mariana D. ; da Silva, Naiara T. ; Colombo, Ana C. ; Reimer, Adriano E. ; Brandao, Marcus L. ; de Oliveira, Amanda R.

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Pharmacology; v. 30, n. 2-3, p. 10-pg., 2019-04-01.

Resumo

Catalepsy - an immobile state in which individuals fail to change imposed postures - can be induced by haloperidol. In rats, the pattern of haloperidol-induced catalepsy is very similar to that observed in Parkinson's disease (PD). As some PD symptoms seem to depend on the patient's emotional state, and as anxiety disorders are common in PD, it is possible that the central mechanisms regulating emotional and cataleptic states interplay. Previously, we showed that haloperidol impaired contextual-induced alarm calls in rats, without affecting footshock-evoked calls. Here, we evaluated the influence of distinct aversive stimulations on the haloperidol-induced catalepsy. First, male Wistar rats were subjected to catalepsy tests to establish a baseline state after haloperidol or saline administration. Next, distinct cohorts were exposed to open-field; elevated plus-maze; open-arm confinement; inescapable footshocks; contextual conditioned fear; or corticosterone administration. Subsequently, catalepsy tests were performed again. Haloperidol-induced catalepsy was verified in all drug-treated animals. Exposure to open-field, elevated plus-maze, open-arm confinement, footshocks, or administration of corticosterone had no significant effect on haloperidol-induced catalepsy. Contextual conditioned fear, which is supposed to promote a more intense fear, increased catalepsy over time. Our findings suggest that only specific defensive circuitries modulate the nigrostriatal system mediating the haloperidol-induced cataleptic state. (AU)

• Processo FAPESP: 16/13141-0 - 46th Annual Meeting of the Society for Neuroscience - Neuroscience 2016
• Beneficiário: Amanda Ribeiro de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Reunião - Exterior
• Processo FAPESP: 13/19280-3 - Efeitos da estimulação aversiva sobre a catalepsia causada pela administração intraperitoneal de haloperidol
• Beneficiário: Nayara Cobra Barreiro Barroca
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 16/04620-1 - Dopamina e neurocininas na mediação da interface sensório-motora do medo e da ansiedade
• Beneficiário: Marcus Lira Brandão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/05544-7 - Influência de eventos estressores sobre a catalepsia induzida pela administração intraperitoneal de haloperidol em ratos
• Beneficiário: Mariana Demarchi Guarda
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica