| Texto completo | |
| Autor(es): |
Francisqueti-Ferron, Fabiane Valentini
;
Togneri Ferron, Artur Junio
;
Garcia, Jessica Leite
;
Vagula de Almeida Silva, Carol Cristina
;
Costa, Mariane Rovero
;
Gregolin, Cristina Schmitt
;
Moreto, Fernando
;
Ferreira, Ana Lucia A.
;
Minatel, Igor Otavio
;
Correa, Camila Renata
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 13, p. 14-pg., 2019-07-01. |
| Resumo | |
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders. (AU) | |
| Processo FAPESP: | 18/15294-3 - Influência da intervenção com gama-orizanol na prevenção da síndrome metabólica cardiorreanal de ratos obesos: participação da carbonilação protéica |
| Beneficiário: | Camila Renata Corrêa |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |