| Texto completo | |
| Autor(es): |
Correa, Rodrigo S.
;
Oliveira, Katia M.
;
Perez, Hiram
;
Plutin, Ana M.
;
Ramos, Raul
;
Mocelo, Raul
;
Castellano, Eduardo E.
;
Batista, Alzir A.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ARABIAN JOURNAL OF CHEMISTRY; v. 12, n. 8, p. 9-pg., 2019-12-01. |
| Resumo | |
In this paper, the title compound was synthesized from N-benzoyl-N',N'-dibenzyl thiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X-ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N',N'-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C-H center dot center dot center dot C, C-H center dot center dot center dot S and H center dot center dot center dot H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, K-b, presenting values of around 10(5) M-1 and 10(4) M-1, respectively. Thermodynamic parameters (Delta G, Delta H and Delta S) suggest spontaneous interactions between complex and the proteins. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University. (AU) | |
| Processo FAPESP: | 13/26559-4 - Modificações estruturais em complexos de Ru(II) biologicamente ativos para o desenho de novos candidatos a metalofármacos |
| Beneficiário: | Rodrigo de Souza Corrêa |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 14/04147-9 - Avaliação das propriedades anticâncer de complexos de rutênio(II) contendo os bioligantes lapachol e lausona |
| Beneficiário: | Katia Mara de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |