Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function following early-life status epilepticus in Wistar rats

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Pacifico, Ana Miria ; Batista, Samuel P. ; Ribeiro, Fernanda T. ; Santos, Pedro B. dos ; Silveira, Gabriel Bruno ; Nascimento, Bruna Pascarelli Pedrico do ; Dias Junior, Eduardo ; Barbosa, Geraldo Henrique L. ; Ribeiro, Miriam Oliveira ; Silva, Sergio Gomes da ; Cysneiros, Roberta M.

• Tipo de documento: Artigo Científico
• Fonte: DATA IN BRIEF; v. 31, p. 9-pg., 2020-08-01.

Resumo

Early-life status epilepticus produces deficit in social interaction and vocalization, enhances anxiety, no cognitive impairment and alters functional connectivity within the hippocampus (CA3-CA1) and between the hippocampus and prefrontal cortex [1-12], but the underlying mechanisms remain unknown. This data article contains behavioral and molecular data of the adult male Wistar rats subjected to early life pilocarpine-induced seizures. Animal's behaviors were assessed to social memory and social motivation, working and reference memories and cognitive flexibility. The brain tissues (hypothalamus, hippocampus, amygdala, and striatum) were probed to gene and protein expression of molecules related to social behavior, reward system and synaptic function. (c) 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) (AU)

• Processo FAPESP: 16/01154-0 - Validação do modelo do Status Epilepticus neonatal para estudo dos transtornos do neurodesenvolvimento
• Beneficiário: Roberta Monterazzo Cysneiros
• Modalidade de apoio: Auxílio à Pesquisa - Regular