MMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: effects of hormonal manipulation

Autor(es)

Rochel-Maia, Sabrina S. ^[1] ; Santos, Fernanda C. A. ^{[2, 3]} ; Vilamaior, Patrcia S. L. ^[3] ; Justulin, Jr., Luis A. ^[4] ; Felisbino, Sergio L. ^[5] ; Goes, Rejane M. ^[3] ; Taboga, Sebastiao R. ^[3]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Inst Biol, Dept Cell Biol, Sao Paulo - Brazil

^[2] Fed Univ Goias UFG, Inst Biol Sci, Dept Morphol, Goias - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci Human & Exact Sci IBILCE, Dept Biol, Sao Paulo - Brazil

^[4] Fed Univ Triangulo Mineiro UFTM, Dept Morphol, Uberaba, MG - Brazil

^[5] Sao Paulo State Univ UNESP, Inst Biosci IBB, Dept Morphol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HISTOLOGY AND HISTOPATHOLOGY; v. 26, n. 11, p. 1423-1434, NOV 2011.
• Citações Web of Science: 3

Resumo

TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with testosterone for 7 or 21 days, were submitted to histological, stereological and immunohistochemical analyses. Stereology of prostatic components showed significant alterations of tissue compartments in the ventral male prostate after castration, especially after 21 days, with a significant increase in stroma. Administration of testosterone led to disorganization in the female prostate, with a significant increase in collagen fibers and smooth muscle cells after 21 days, along with the development of epithelial lesions such as PINs. MMP-2 increased after 21 days of castration in males; however, the TIMP-2 immunoreaction for this group was weak or absent. In females, the expression of MMP-2 appeared to decrease after 7 days of treatment with testosterone, but after 21 days, both epithelium and stroma showed a stronger reaction for MMP-2 than the controls. The expression of TIMP-2 in the treated females was similar to its expression in the castrated males. We conclude that the distribution of MMPs and TIMPs in both male and female prostates is altered by androgen manipulation, but the mechanism of stromal regulation appears to be distinct between genders because both the lack of T in castrated males and the excess levels of T in treated females lead to the same effect. (AU)

• Processo FAPESP: 06/06985-5 - Modulação androgênica da expressão de MMP-2 e MMP-9 e serino proteases na próstata masculina e feminina de gerbilos
• Beneficiário: Sabrina Santos Rochel Maia
• Modalidade de apoio: Bolsas no Brasil - Doutorado