Rational design of polyelectrolyte complexes based on bevacizumab and gellan gum with a surface modified with chitosan

Autor(es)

Carvalho, Suzana Gonsalves ; dos Santos, Aline Martins ; Cardoso, Ana Julia Rocha ; Meneguin, Andreia Bagliotti ; Ferreira, Leonardo Miziara Barboza ; Chorilli, Marlus ; Gremiao, Maria Palmira Daflon

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS TODAY COMMUNICATIONS; v. 40, p. 8-pg., 2024-08-01.

Resumo

Bevacizumab (BVZ) is an anti-angiogenic monoclonal antibody used to treat diseases such as various types of cancer. However, its parenteral administration causes several side effects and oral administration is limited due to the integrity of these macromolecules in the face of the extreme conditions of the gastrointestinal tract. To overcome these limitations, the study of drug delivery systems becomes a promising strategy to increase the efficiency of BVZ therapeutic delivery. Therefore, it is important that drug delivery systems are meticulously designed and that their physicochemical properties are understood. The objective of the present study was to develop nanoparticles through polyelectrolytic complexation between polysaccharides and polyampholytes, without the use of organic solvents, and to evaluate the influence of pH and molecular weight on particle formation. Different proportions of polymers were tested to obtain the nanoparticles, exhibiting average diameters in the range of 222.6-412.1 nm, zeta potential of -16.3 to -40 mV, and polydispersity index of similar to 0.16-0.53. Complexation with chitosan promoted charge inversion (> +40 mV), in addition to increasing particle diameter and association efficiency, ranging from 29 % to approximately 60 %. (AU)

• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 22/14075-1 - Sistemas multifuncionais baseados em polissacarídeos para liberação colón específica de pós-bióticos e seu potencial para aplicação no tratamento e prevenção de doenças inflamatórias intestinais
• Beneficiário: Suzana Gonçalves Carvalho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/10761-5 - Sistemas multifuncionais destinados à liberação cólon específica do bevacizumabe para o tratamento do Câncer Colorretal
• Beneficiário: Suzana Gonçalves Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado