Unraveling the complex interplay: immunopathology and immune evasion strategies of alphaviruses with emphasis on neurological implications

Autor(es)

Souza, Raquel de Oliveira ; Duarte Junior, Jose Wandilson Barboza ; Della Casa, Victoria Simoes ; Rosa, Daniela Santoro ; Renia, Laurent ; Claser, Carla

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 14, p. 18-pg., 2024-08-15.

Resumo

Arthritogenic alphaviruses pose a significant public health concern due to their ability to cause joint inflammation, with emerging evidence of potential neurological consequences. In this review, we examine the immunopathology and immune evasion strategies employed by these viruses, highlighting their complex mechanisms of pathogenesis and neurological implications. We delve into how these viruses manipulate host immune responses, modulate inflammatory pathways, and potentially establish persistent infections. Further, we explore their ability to breach the blood-brain barrier, triggering neurological complications, and how co-infections exacerbate neurological outcomes. This review synthesizes current research to provide a comprehensive overview of the immunopathological mechanisms driving arthritogenic alphavirus infections and their impact on neurological health. By highlighting knowledge gaps, it underscores the need for research to unravel the complexities of virus-host interactions. This deeper understanding is crucial for developing targeted therapies to address both joint and neurological manifestations of these infections. (AU)

• Processo FAPESP: 21/13004-0 - Desenvolvimento de vacinas de subunidade contra o SARS-CoV-2 baseadas no domínio de ligação ao receptor (RBD)
• Beneficiário: Daniela Santoro Rosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/06970-0 - Identificação do mecanismo de patogenicidade induzido durante coinfecção com vírus Mayaro e Plasmodium berghei ANKA
• Beneficiário: José Wandilson Barboza Duarte Júnior
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/24470-0 - Estudo das alterações imunopatológicas induzidas durante a coinfecção com Alphavirus e Malária em modelo murino
• Beneficiário: Carla Claser
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 22/13236-1 - Desenvolvimento de modelos experimentais em C57BL/6 para estudos de coinfecção com o vírus Mayaro e Chikungunya
• Beneficiário: Victória Simões Della Casa
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 22/15124-6 - Estudo da modulação da resposta imune humoral e celular induzida pelos vírus Mayaro e Chikungunya em camundongos coinfectados
• Beneficiário: Raquel de Oliveira Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado