An Improved Protocol for the Synthesis of Carbonyl Sulfoxonium Ylides

Autor(es)

de Souza, Joao H. ; Vargas, Jorge A. M. ; Burtoloso, Antonio C. B.

• Tipo de documento: Artigo Científico
• Fonte: SYNTHESIS-STUTTGART; v. 56, n. 05, p. 5-pg., 2024-01-18.

Resumo

An improved protocol for the synthesis of carbonyl sulfoxonium ylides from the reaction between trimethylsulfoxonium iodide and reactive carboxylic acid derivatives is described. In a one-pot, two-step sequence, these sulfoxonium ylides could be obtained in up to 81% yield with shorter reaction times and lesser equivalent numbers of the reactants when compared to the previous methods. These improvements make the method less expensive and ideal for larger scale preparations as well, not necessitating excess of the trialkylsulfoxonium salt starting material. An easier workup procedure, avoiding solvent extraction, is also discussed and facilitates product isolation. (AU)

• Processo FAPESP: 20/15230-5 - Centro de Pesquisa e Inovação de Gases de Efeito Estufa - RCG2I
• Beneficiário: Julio Romano Meneghini
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia
• Processo FAPESP: 21/06549-0 - Preparação de isocianatos e polióis de importância industrial a partir de CO2 e plataformas moleculares obtidas a partir da biomassa e seu uso na síntese de poliuretanos
• Beneficiário: Jorge Andrés Mora Vargas
• Modalidade de apoio: Bolsas no Brasil - Doutorado