Physical Exercise-Induced FGF-21 to Fight Obesity: An Update Review

Autor(es)

Vecchiatto, Bruno ; de Castro, Thiago Lucas ; Muller, Cynthia R. ; Azevedo-Martins, Anna Karenina ; Evangelista, Fabiana S.

• Tipo de documento: Artigo Científico
• Fonte: OBESITIES; v. 2, n. 4, p. 8-pg., 2022-12-01.

Resumo

Fibroblast growth factor 21 (FGF-21) is a protein that is involved in the regulation of glucose, lipids, and energy metabolism. To act on target tissues, endocrine FGF-21 binds preferably to FGF receptor 1 (FGFR1) in the presence of the coreceptor named beta-klotho (KLB). Some of the effects of FGF-21 include increased fatty acid oxidation, glucose uptake, insulin sensitivity, and thermogenesis, which can regulate body weight and glycemia control. By exerting such metabolic effects, the therapeutic potential of FGF-21 for the treatment of obesity and diabetes has been investigated. Physical exercise has been widely used for the prevention and treatment of obesity. Several mechanisms mediate the effects of physical exercise, including the FGF-21 pathway. Studies have shown that physical exercise increases the concentration of circulating and tissue FGF-21 in animals, while contradictory results are still observed in humans. Considering the metabolic role of FGF-21 and the chance of physical exercise to induce FGF-21 secretion, in this review we explore the potential of physical exercise-induced FGF-21 modulation as a strategy for prevention and treatment of obesity. (AU)

• Processo FAPESP: 20/12005-0 - Cardioproteção no diabetes mediada pelo treinamento físico aeróbio e associação com o fator de crescimento de fibroblastos 21 (FGF21)
• Beneficiário: Bruno Vecchiatto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 20/15748-4 - Cardioproteção no Diabetes mediada pelo treinamento físico aeróbio e o papel do tecido adiposo marrom
• Beneficiário: Fabiana de Sant'Anna Evangelista
• Modalidade de apoio: Auxílio à Pesquisa - Regular