| Texto completo | |
| Autor(es): Mostrar menos - |
Moraes, Gustavo Simao
;
Albach, Thais
;
Sugio, Carolina Yoshi Campos
;
Cachoeira, Victoria Schlumberger
;
Kiratcz, Falyne
;
Tozetto, Nathaly Mayer
;
Pedroso, Thaynara Aparecida Alves
;
Campagnoli, Eduardo Bauml
;
Claudino, Marcela
;
dos Santos, Fabio Andre
;
Neppelenbroek, Karin Hermana
;
Urban, Vanessa Migliorini
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Applied Microbiology; v. 135, n. 6, p. 8-pg., 2024-06-04. |
| Resumo | |
Aim This study investigated the effectiveness of a drug-modified tissue conditioner in an animal model of denture stomatitis.Methods and Results Wistar rats wore a Candida albicans-contaminated palatal device for 4 days. Next, nystatin (Nys) or chlorhexidine (Chx) were added to a tissue conditioner in their raw or beta-cyclodextrin-complexed (beta CD) forms at their minimum inhibitory concentrations. As controls, one group was not subjected to any procedure (NC), one group used sterile devices, one group had denture stomatitis but was not treated (DS), and another had the devices relined with the tissue conditioner without the addition of any drug (Soft). After 4 days of treatment, treatment effectiveness was assessed visually, histologically, and through CFU count, and myeloperoxidase (MPO) and N-acetylglucosaminidase (NAG) assays. Rats from the Soft, Nys, Nys:beta CD, and Chx groups presented a significant decrease in the microbial load compared with the untreated group. Treatment groups showed lower MPO and NAG activity compared to the non-treated group.Conclusions The addition of antifungals to a soft tissue conditioner can be a promising approach for denture stomatitis treatment. (AU) | |
| Processo FAPESP: | 17/07314-1 - Avaliação clínica da adição de antifúngicos a reembasador resiliente temporário no tratamento da estomatite protética |
| Beneficiário: | Karin Hermana Neppelenbroek |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/22996-1 - Resposta tecidual em modelo animal de condicionador de tecido contendo complexo de inclusão antifúngico: ²-ciclodextrina para tratamento de estomatite protética |
| Beneficiário: | Carolina Yoshi Campos Sugio |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |