Environmentally induced antinociception and hyperalgesia in rats and mice

Autor(es)

Cornelio, Alianda Maira ^{[1, 2, 3]} ; Mendes-Gomes, Joyce ^{[1, 4]} ; Fugimoto, Juliana Sayuri ^[1] ; Morgan, Michael M. ^[3] ; Nunes-de-Souza, Ricardo Luiz ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] UNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP - Brazil

^[2] UNESP, UFSCar, Programa Interinst Posgrad Ciencias Fisiol, BR-14801902 Araraquara, SP - Brazil

^[3] Washington State Univ Vancouver, Dept Psychol, Vancouver, WA 98686 - USA

^[4] USP, FFCLRP, Programa Posgrad Psicobiol, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brain Research; v. 1415, p. 56-62, SEP 30 2011.
• Citações Web of Science: 10

Resumo

Stress can enhance and inhibit nociception depending on the situation. Thus, simply shifting the context from the elevated plus maze (EPM) which has been shown to produce stress-induced antinociception to a different environment could produce drastic and rapid changes in nociception. The present experiment tested this hypothesis by assessing nociception in rats and mice during and immediately after removal from the maze. Experiment 1 found hyperalgesia in female and male rats tested on the hot plate immediately after exposure to the elevated plus maze. This hyperalgesia occurred with or without the added stress of a hind paw formalin injection and regardless of whether rats were exposed to an EPM with open (oEPM) or enclosed (eEPM) arms despite a clear antinociceptive effect while on the oEPM. Experiment 2 showed a similar shift from antinociception to nociception on the formalin test in mice immediately after removing them from the EPM. These data demonstrate that a mild stressor such as the EPM can produce both antinociception and hyperalgesia depending on the context. This shift from antinociception to hyperalgesia occurs rapidly and is evident in mice, male and female rats, and with the hot plate and formalin tests. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 05/01988-3 - Papel das porções dorsal e ventrolateral da matéria cinzenta periaquedutal de camundongos na modulação das reações comportamentais defensivas e antinocicepção induzidas por situações aversivas
• Beneficiário: Joyce Mendes Gomes Tessari
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto