| Texto completo | |
| Autor(es): |
Marena, Gabriel Davi
;
do Nascimento, Andre Luiz Carneiro Soares
;
Carvalho, Gabriela Correa
;
Sabio, Rafael Miguel
;
Bauab, Tais Maria
;
Chorilli, Marlus
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOFOULING; v. 40, n. 9, p. 15-pg., 2024-08-21. |
| Resumo | |
Candida auris is a multidrug-resistant yeast that has seen a worrying increase during the COVID-19 pandemic. Give7/n this, new therapeutic options, such as controlled-release nanomaterials, may be promising in combating the infection. Therefore, this study aimed to develop amphotericin B (AmB) and micafungin (MICA)-loaded nanoemulsions (NEMA) and evaluated against biofilms of C. auris. Nanoemulsions (NEs) were characterized and determined minimum inhibitory concentration MIC90, checkerboard and anti-biofilm. NEMA presented a size of 53.7 and 81.4 nm for DLS and NTA, respectively, with good stability and spherical morphology. MICAmB incorporated efficiency was 88.4 and 99.3%, respectively. The release results show that AmB and MICA obtained a release of 100 and 63.4%, respectively. MICAmB and NEMA showed MIC90 values of 0.015 and 0.031 ug/mL, respectively and synergism. NEMA showed greater metabolic inhibition and morphological changes in mature biofilms. This drugs combination and co-encapsulation proved to be a promising therapy against C. auris biofilms. (AU) | |
| Processo FAPESP: | 18/23357-5 - Cocristais multicomponentes de Anti-Inflamatórios Não Esteróides (AINEs) e Inibidores de Bomba de Prótons (IBPs): desenvolvimento, caracterização e avaliação biológica in vitro e in vivo |
| Beneficiário: | André Luiz Carneiro Soares do Nascimento |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/26821-7 - Nano-in-nano contendo curcumina e cloridrato de benzidamina para tratamento de Candidíase Vulvovaginal: do desenvolvimento à aplicação biológica in vitro e in vivo |
| Beneficiário: | Gabriela Corrêa Carvalho |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 19/09831-9 - Nanoemulsões para co-encapsulação de anfotericina B e micafungina: desenvolvimento, caracterização e avaliação do potencial in vitro e in vivo contra Candida auris |
| Beneficiário: | Gabriel Davi Marena |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |