Modulating gut microbiota by paraprobiotics: Mechanisms, advantages, and challenges

Autor(es)

Yolmeh, Mahmoud ; Xavier-Santos, Douglas ; Sant' Ana, Anderson S.

• Tipo de documento: Artigo Científico
• Fonte: FOOD BIOSCIENCE; v. 60, p. 11-pg., 2024-05-09.

Resumo

Imbalance in the gut microbiota (GM), changes in their functions and metabolic activities, known as dysbiosis, can harm human health. Therefore, the prevention of dysbiosis and the improvement of GM are vital to maintaining health. In recent years, the importance of inactivated probiotics, known as paraprobiotics, has increased because of their health-promoting benefits (HPB) and advantages over probiotics. This article evaluates the recently published literature about the effects of paraprobiotics on modulating/changing GM and discusses their potential mechanisms, mainly attributed to the cell fragments. In addition, the different methods of using paraprobiotics (direct and within the food matrix) are evaluated, and which method has better beneficial effects towards GM is shown. Since the beneficial effects of paraprobiotics towards GM are affected through several agents, such as the type of the probiotic strain, the inactivation method; the optimization of conditions is crucial to achieve an appropriate GM improvement performance. Paraprobiotics increased the abundance of Lactobacillales, Bifidobacteriales, and Ruminococcaceae in the GM, but the abundance of Corynebacterium, EscherichiaShigella, Plesiomonasare decreased. Using paraprobiotics in a carbohydrate matrix as a food carrier can be a much more promising method to improve GM than directly or within foods with high protein contents. (AU)

• Processo FAPESP: 21/07182-3 - Expandindo o conceito de bactérias benéficas - a estabilidade durante o armazenamento e o papel dos paraprobióticos na saúde e microbiota intestinal de ratos hipercolesterolêmicos
• Beneficiário: Mahmoud Yolmeh
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 22/00190-3 - Avaliação do potencial posbiótico de Lacticaseibacillus rhamnosus GG inativado via spray drying sobre os efeitos anti-inflamatórios in vitro e seu impacto em ratos Wistar obesos
• Beneficiário: Douglas Xavier dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 23/13146-5 - Avaliação do processo de retenção de ácidos biliares pela superfície celular de Lacticaseibacillus rhamnosus GG inativado via spray drying sob simulação de digestão in vitro
• Beneficiário: Douglas Xavier dos Santos
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado