| Texto completo | |
| Autor(es): |
Santos, Julio Cesar Claudino dos
;
Reboucas, Conceicao da Silva Martins
;
Oliveira, Leandro Freitas
;
Cardoso, Fabrizio dos Santos
;
Nascimento, Tyciane de Souza
;
Oliveira, Alfaete Vieira
;
Lima, Micael Porto Portela
;
de Andrade, Geanne Matos
;
Brito, Gerly Anne de Castro
;
Viana, Glauce Socorro de Barros
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROBIOLOGY OF AGING; v. 132, p. 13-pg., 2023-10-13. |
| Resumo | |
Parkinson's disease (PD) is a widespread neurodegenerative condition affecting millions globally. This in-vestigation centered on the gut-brain axis in a rotenone-induced PD rat model. Researchers monitored behavioral shifts, histological modifications, neurodegeneration, and inflammation markers throughout the rats' bodies. Results revealed that rotenone-treated rats displayed reduced exploration (p = 0.004) and motor coordination (p < 0.001), accompanied by decreased Nissl staining and increased alpha-synuclein im-munoreactivity in the striatum (p = 0.009). Additionally, these rats exhibited weight loss (T3, mean = 291.9 +/- 23.67; T19, mean = 317.5 +/- 17.53; p < 0.05) and substantial intestinal histological alterations, such as shor-tened villi, crypt architecture loss, and inflammation. In various regions, researchers noted elevated im-munoreactivity to ionized binding adapter molecule (IBA)-1 (p < 0.05) and reduced immunoreactivity to glial fibrillary acidic protein (p < 0.05) and S100B (p < 0.001), indicating altered glial cell activity. Overall, these findings imply that PD is influenced by gut-brain axis changes and may originate in the intestine, impacting bidirectional gut-brain communication.(c) 2023 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 21/06473-4 - Potencial terapêutico da fotobiomodulação em ratos com Epilepsia: análise da frequência de crises epilépticas, desempenho cognitivo, e perfil metabolômico cerebral |
| Beneficiário: | Fabrízio dos Santos Cardoso |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |