Ascorbic acid as a modulator of inflammatory response against Candida albicans

Autor(es)

Moreira Milhan, Noala Vicensoto ; Graca Sampaio, Aline da ; Koga-Ito, Cristiane Yumi ; Bruzzaniti, Angela

• Tipo de documento: Artigo Científico
• Fonte: FUTURE MICROBIOLOGY; v. 19, n. 7, p. 10-pg., 2024-04-17.

Resumo

Aim: To evaluate the behavior of oral keratinocytes in the presence of Vitamin C (Vit C) and its anti-inflammatory potential. Materials & methods: Oral keratinocytes were initially exposed to 0.1-2.5 mM of Vit C and the metabolic activity and cell migration were evaluated using MTS assay and Ibidi culture inserts, respectively. After, the cells were challenged with Candida albicans and inflammatory markers were analyzed by qPCR. Results: The treatment was not cytotoxic, and the highest concentrations increased the metabolic activity at 24 h. Vit C delayed the cell migration at 48 and 72 h. Interestingly, it downregulated the genes IL-8 and IL-1 beta. Conclusion: Vit C could be an interesting adjuvant to anti-fungal treatment due to its anti-inflammatory potential. (AU)

• Processo FAPESP: 22/04723-6 - Aplicação do plasma de baixa temperatura no tratamento de mucosite usando modelo organotípico 3D
• Beneficiário: Aline da Graça Sampaio
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 22/04598-7 - O efeito do tratamento sinérgico da vitamina C e plasma de baixa temperatura na candidíase induzida em mucosa oral reconstituída
• Beneficiário: Noala Vicensoto Moreira Milhan
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 19/05856-7 - Aplicações de plasmas atmosféricos não-térmicos na odontologia: da bancada para a clínica
• Beneficiário: Cristiane Yumi Koga Ito
• Modalidade de apoio: Auxílio à Pesquisa - Temático