| Texto completo | |
| Autor(es): |
Lima, Bruna de Souza
;
Sanches, Ana Paula Varela
;
Ferreira, Maira Schuchter
;
de Oliveira, Josilene Lopes
;
Cleal, Jane K.
;
Ignacio-Souza, Leticia
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE; v. 1870, n. 1, p. 11-pg., 2023-10-03. |
| Resumo | |
Maternal obesity could impact offspring's health. During "critical period" such as pregnancy insults have a significant role in developing chronic diseases later in life. Literature has shown that diet can play a major role in essential metabolic and development processes on fetal outcomes. Moreover, the placenta, an essential organ developed in pregnancy, seems to have its functions impaired based on pre-gestational and gestational nutri-tional status. Specifically, a high-fat diet has been shown as a potential nutritional insult that also affects the maternal-placental axis, which is involved in offspring development and outcome. Moreover, some classes of nutrients are associated with pregnancy complications such as reduced intake of micronutrients and diabetes, preeclampsia, and preterm delivery. Thus, we will summarize the current literature on maternal environment factors that impacts the placental development and consequently the fetal an offspring health, or the maternal -placental axis, and this on fetal outcomes, metabolism, and development. (AU) | |
| Processo FAPESP: | 17/11608-0 - Programação obesogênica: o papel do ambiente materno e a interface feto-placentária |
| Beneficiário: | Letícia Ignácio de Souza Zimmermann |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/16726-4 - Estresse de retículo endoplasmático como modulador da resposta placentária à obesidade materna: implicações para a hipótese do DOHaD |
| Beneficiário: | Bruna de Souza Lima |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |