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| Autor(es): Mostrar menos - |
da Silva, Pedro Henrique Rodrigues
;
Leffa, Douglas T.
;
Luethi, Matthias S.
;
Silva, Roberta F.
;
Ferrazza, Carolina Prietto
;
Picon, Felipe Almeida
;
Grevet, Eugenio Horacio
;
Bau, Claiton Henrique Dotto
;
Rovaris, Diego Luiz
;
Razza, Lais B.
;
Caumo, Wolnei
;
Camprodon, Joan A.
;
Rohde, Luis Augusto Paim
;
Brunoni, Andre R.
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PSYCHIATRIC RESEARCH; v. 177, p. 9-pg., 2024-07-31. |
| Resumo | |
Background: Home-based transcranial direct current stimulation (Hb-tDCS) is a non-invasive brain stimulation technique that utilizes low-intensity electric currents delivered via scalp electrodes to modulate brain activity. It holds significant promise for addressing inattention in adults with attention-deficit/hyperactivity disorder (ADHD). However, its effectiveness varies among individuals, and predicting outcomes remains uncertain, partially due to the influence of individual differences in ADHD-related brain anatomy. Methods: We analyzed data from a subsample, composed by twenty-nine adult patients with ADHD, of the Treatment of Inattention Symptoms in Adult Patients with ADHD (TUNED) trial. Fourteen patients underwent active anodal right cathodal left dorsolateral prefrontal cortex (DLPFC) Hb-tDCS for 4 weeks and fifteen received sham-related tDCS intervention. Inattention outcome was evaluated at both baseline and endpoint (4th week). Baseline structural measures of the DLPFC, anterior cingulate cortex (ACC) and subcortical structures, previously associated with ADHD, were quantified. Several linear mixed models, with a three-way interaction between the fixed predictors brain volume or thickness, time, and treatment were calculated. Multiple comparison corrections were applied using the Benjamini-Hochberg method. Results: Baseline volume of the left DLPFC regions middle frontal gyrus (t (25) = 3.33, p-adjusted = 0.045, Cohen's d = 1.33, 95% CI = [0.45, 2.19]), inferior frontal gyrus (orbital part) (t (25) = 3.10, p-adjusted = 0.045, Cohen's d = 1.24, 95% CI = [0.37, 2.08]), and of the left ACC supragenual (t (25) = 3.15, p-adjusted = 0.045, Cohen's d = 1.26, 95% CI = [0.39, 2.11]) presented significant association with the inattentive score improvement only in the active tDCS group. More specifically, the smaller these regions were, the more the symptoms improved following anodal right cathodal left DLPFC Hb-tDCS. Conclusion: Hb-tDCS was associated with greater improvement in brain areas related to attention regulation. Brain MRI can be potentially used to predict clinical response to tDCS in ADHD adults. (AU) | |
| Processo FAPESP: | 21/10574-0 - Aumento de acurácia prognóstica em pacientes deprimidos utilizando diferentes intervenções de neuromodulação não-implantáveis |
| Beneficiário: | Matthias Stephan Luthi |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/06009-6 - Terapias de neuromodulação não-implantáveis: uma perspectiva para o cérebro deprimido |
| Beneficiário: | Geraldo Busatto Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 22/03266-0 - Investigação de avaliações de neuroimagem e modelagem de fluxo de corrente como biomarcadores de engajamento alvo e preditores de terapias convulsivas |
| Beneficiário: | Pedro Henrique Rodrigues da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/10861-7 - Avaliação multimodal dos efeitos da estimulação transcraniana por corrente contínua e estimulação theta-burst no funcionamento do córtex pré-frontal: um estudo Fase-I bilateral, placebo-controlado, fatorial |
| Beneficiário: | Andre Russowsky Brunoni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |