Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults

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Urban, Britta C. ; Goncalves, Andre N. A. ; Loukov, Dessi ; Passos, Fernando M. ; Reine, Jesus ; Gonzalez-Dias, Patricia ; Solorzano, Carla ; Mitsi, Elena ; Nikolaou, Elissavet ; O'Connor, Daniel ; Collins, Andrea M. ; Adler, Hugh ; Pollard, Andrew ; Rylance, Jamie ; Gordon, Stephen B. ; Jochems, Simon P. ; Nakaya, Helder I. ; Ferreira, Daniela M.

• Tipo de documento: Artigo Científico
• Fonte: MUCOSAL IMMUNOLOGY; v. 17, n. 5, p. 17-pg., 2024-10-09.

Resumo

Streptococcus pneumoniae colonization in the upper respiratory tract is linked to pneumococcal disease development, predominantly affecting young children and older adults. As the global population ages and comorbidities increase, there is a heightened concern about this infection. We investigated the immunological responses of older adults to pneumococcalcontrolled human infection by analyzing the cellular composition and gene expression in the nasal mucosa. Our comparative analysis with data from a concurrent study in younger adults revealed distinct gene expression patterns in older individuals susceptible to colonization, highlighted by neutrophil activation and elevated levels of CXCL9 and CXCL10. Unlike younger adults challenged with pneumococcus, older adults did not show recruitment of monocytes into the nasal mucosa following nasal colonization. However, older adults who were protected from colonization showed increased degranulation of cluster of differentiation 8+ T cells, both before and after pneumococcal challenge. These fi ndings suggest age-associated cellular changes, in particular enhanced mucosal inflammation, that may predispose older adults to pneumococcal colonization. (AU)

• Processo FAPESP: 18/14933-2 - Biologia integrativa aplicada à saúde humana
• Beneficiário: Helder Takashi Imoto Nakaya
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2