| Texto completo | |
| Autor(es): |
Fugio, Lais Brigliadori
;
Silva, Gabriel
;
Ferraz, Camila Lopes
;
Trevisan, Glauce Lunardelli
;
Coeli-Lacchini, Fernanda Borchers
;
Garcia, Cristiana Bernadelli
;
Sousa, Lucas Oliveira
;
Malta, Tathiane Maistro
;
Gil, Cristiane Damas
;
Leopoldino, Andreia Machado
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH; v. 1871, n. 1, p. 17-pg., 2023-10-31. |
| Resumo | |
Sphingosine-1-phosphate (S1P) signaling has been widely explored as a therapeutic target in cancer. Sphingosine kinase 2 (SK2), one of the kinases that phosphorylate sphingosine, has a cell type and cell location-dependent mechanism of action, so the ability of SK2 to induce cell cycle arrest, apoptosis, proliferation, and survival is strongly influenced by the cell-context. In contrast to SK1, which is widely studied in different types of cancer, including head and neck cancer, the role of SK2 in the development and progression of oral cancer is still poorly understood. In order to elucidate SK2 role in oral cancer, we performed the overexpression of SK2 in non-tumor oral keratinocyte cell (NOK SK2) and in oral squamous cell carcinoma (HN12 SK2), and RNA interference for SK2 in another oral squamous cell carcinoma (HN13 shSK2). In our study we demonstrate for the first time that accumulation of SK2 can be a starting point for oncogenesis and transforms a non-tumor oral keratinocyte (NOKSI) into highly aggressive tumor cells, even acting on cell plasticity. Furthermore, in oral metastatic cell line (HN12), SK2 contributed even more to the tumorigenesis, inducing proliferation and tumor growth. Our work reveals the intriguing role of SK2 as an oral tumor promoter and regulator of different pathways and cellular processes. (AU) | |
| Processo FAPESP: | 18/14225-8 - Estudo das proteínas esfingosina quinase 2 e SET na sinalização de esfingolipídios em Câncer de Cabeça e Pescoço |
| Beneficiário: | Lais Brigliadori Fugio |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 16/19103-2 - SET e esfingolipídeos em câncer de cabeça e pescoço: sinalização, alvos e terapia antitumoral |
| Beneficiário: | Andréia Machado Leopoldino |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/00101-5 - Diferentes estratégias experimentais e abordagens para o estudo de marcadores moleculares em câncer |
| Beneficiário: | Glauce Lunardelli Trevisan |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |
| Processo FAPESP: | 18/17480-9 - Estudo da SET e esfingolipídeos em câncer de cabeça e pescoço: sinalização, alvos e terapia antitumoral |
| Beneficiário: | Gabriel da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |