| Texto completo | |
| Autor(es): Mostrar menos - |
Euclydes, Veronica
;
Braga, Caio I. S.
;
Gouveia, Gisele
;
Martinez, Raquel C. R.
;
Camilo, Caroline
;
Simoes, Sergio N.
;
Martins-Jr, David C.
;
Fracolli, Lislaine
;
Argeu, Adriana
;
Ferraro, Alexandre
;
Matijasevich, Alicia
;
Fatori, Daniel
;
Miguel, Euripedes C.
;
Polanczyk, Guilherme, V
;
Brentani, Helena
Número total de Autores: 15
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| Tipo de documento: | Artigo Científico |
| Fonte: | BRAIN, BEHAVIOR, & IMMUNITY - HEALTH; v. 40, p. 11-pg., 2024-08-05. |
| Resumo | |
Background and objectives: The neurodevelopment of the offspring is suggested to be influenced by the maternal immune system's responses throughout pregnancy, which in turn is also vulnerable to maternal psychosocial stress conditions. Therefore, our main goal was to investigate whether maternal peripheral immunological biomarkers (IB) during two stages of gestation are associated with distinct neurodevelopmental trajectories in the first two years of life. As a second goal, we also explored the association between maternal distal (childhood) and proximal (gestation) stressful experiences and the immunological markers assessed during pregnancy. Methods: Maternal childhood trauma, depressive and anxiety symptoms, and peripheral IB (IFN gamma, IL-10, IL1 beta , IL6, IL8, TNF alpha, EGF, IL13, IL17, IL1Ra and IL4) were measured at baseline (8-16 weeks of pregnancy) and at 30 weeks of pregnancy in 160 women. The participants had the blood samples collected from two randomized clinical trials conducted by the same team and methods in the same community. A Principal Component Analysis (PCA) was implemented to create meaningful composite variables that describe the cytokines joint variation. Finally, linear mixed-effects modeling was used to investigate the influence of inflammatory biomarkers, maternal childhood trauma, anxiety, and depressive symptoms on Bayley's III scores trajectories. Results: The IB profile during the 3rd trimester of pregnancy predicted the offspring's neurodevelopmental trajectories in the first two years of life. The components derived from PCA were important predictors and captured different immune responses, reflecting both pro- and anti-inflammatory states. Maternal stressful experiences did not correlate with the immunological markers. Although not a reliable predictor alone, maternal psychosocial stress at the 1st trimester of pregnancy interacted with the mother's immune response while predicting the neurodevelopmental scores during the first two years of life. Conclusions: Our results underscore the importance of the maternal immune response during pregnancy in shaping the neurodevelopmental trajectory of the offspring. Additionally, we observed that the maternal distress at the early stages of pregnancy has an incremental effect on the neurodevelopmental outcome but depends upon the immune response. (AU) | |
| Processo FAPESP: | 18/18560-6 - Integração de dados para busca de marcadores biológicos de transtornos do neurodesenvolvimento |
| Beneficiário: | Helena Paula Brentani |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/16376-3 - Determinação do risco poligênico para caracterização de exposição ao estresse gestacional |
| Beneficiário: | Catarina dos Santos Gomes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 23/01343-0 - Investigando dinâmicas do efeito do estresse sobre a expressão de sncRNA em espermatozoides humanos |
| Beneficiário: | Caio Isaias da Silva Braga |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |
| Processo FAPESP: | 16/22455-8 - Intervenções na primeira infância e trajetórias de desenvolvimento cognitivo, social e emocional |
| Beneficiário: | Guilherme Vanoni Polanczyk |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/21934-5 - Estatística de redes: teoria, métodos e aplicações |
| Beneficiário: | André Fujita |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/15590-1 - Integração de dados de escores de risco poligênico e marcadores de risco epigenéticos para predição de neurodesenvolvimento em crianças em situação de vulnerabilidade psicossocial |
| Beneficiário: | Verônica Luiza Vale Euclydes Colovati |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 21/00485-0 - Integração de dados para construção de modelos estatisticos preditores de neurodesenvolvimento em função da exposição a estressores |
| Beneficiário: | Caio Isaias da Silva Braga |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |