| Texto completo | |
| Autor(es): Mostrar menos - |
Leite, Jefferson Antonio
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Menezes, Luisa
;
Martins, Eloisa
;
Rodrigues, Tamara Silva
;
Tavares, Lucas
;
Ebering, Anna
;
Schelmbauer, Carsten
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Cebinelli, Guilherme C. Martelossi
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Zinina, Valeriya
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Golden, Artemiy
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Soshnikova, Natalia
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Zamboni, Dario S.
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Cunha, Fernando Q.
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Huber, Magdalena
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Silva, Joao Santana
;
Waisman, Ari
;
Carlos, Daniela
;
Camara, Niels Olsen Saraiva
Número total de Autores: 18
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| Tipo de documento: | Artigo Científico |
| Fonte: | ISCIENCE; v. 26, n. 11, p. 19-pg., 2023-10-14. |
| Resumo | |
AIM2 is an interferon-inducible HIN-200 protein family member and is well-documented for its roles in innate immune responses as a DNA sensor. Recent studies have highlighted AIM2's function on regulatory T cells (Treg) and follicular T cells (Tfh). However, its involvement in Th17 cell differentiation remains unclear. This study reveals that AIM2 promotes Th17 cell differentiation. AIM2 deficiency decreases IL-17A production and downregulates key Th17 associated proteins (ROR gamma t, IL-1R1, IL-23R). AIM2 is located in the nucleus of Th17 cells, where it interacts with ROR gamma t, enhancing its binding to the Il17a promoter. The absence of AIM2 hinders naive CD4 T cells from differentiating into functional Th17 cells and from inducing colitis in Rag1(-/-) mice. This study uncovers AIM2's role as a regulator of Th17 cell transcriptional programming, highlighting its potential as a therapeutic target for Th17 cell-mediated inflammatory diseases. (AU) | |
| Processo FAPESP: | 18/14815-0 - Estudo do perfil do microbioma intestinal e do potencial terapêutico de estratégias de intervenção na imunopatogenia do Diabetes tipo 1 e 2 |
| Beneficiário: | Daniela Carlos Sartori |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais |
| Beneficiário: | Niels Olsen Saraiva Câmara |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/19435-3 - Papel de danos no DNA e função mitocondrial em envelhecimento vascular, imune e neurológico (DNA MoVINg) |
| Beneficiário: | Carlos Frederico Martins Menck |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |