Subcellular particles for characterization of host-parasite interactions

Autor(es)

Kozela, Ewa ; Meneghetti, Paula ; Regev-Rudzki, Neta ; Torrecilhas, Ana Claudia ; Porat, Ziv

• Tipo de documento: Artigo Científico
• Fonte: Microbes and Infection; v. 26, n. 7, p. 10-pg., 2024-09-05.

Resumo

Parasitic diseases remain a major global health problem for humans. Parasites employ a variety of strategies to invade and survive within their hosts and to manipulate host defense mechanisms, always in the pathogen's favor. Extracellular vesicles (EVs), membrane-bound nanospheres carrying a variety of bioactive compounds, were shown to be released by the parasites during all stages of the infection, enabling growth and expansion within the host and adaptation to frequently changing environmental stressors. In this review, we discuss how the use of existing nanotechnologies and high-resolution imaging tools assisted in revealing the role of EVs during parasitic infections, enabling the quantitation, visualization, and detailed characterization of EVs. We discuss here the cases of malaria, Chagas disease and leishmaniasis as examples of parasitic neglected tropical diseases (NTDs). Unraveling the EVs' role in the NTD pathogenesis may enormously contribute to their early and reliable diagnostic, effective treatment, and prevention. (c) 2024 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 20/07870-4 - Mecanismos de adaptação de tripanossomatídeos ao hospedeiro através de controle da transcrição, síntese proteica e secreção de vesículas extracelulares
• Beneficiário: Ana Claudia Trocoli Torrecilhas
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/15909-0 - Estudos do mecanismos de secreção de vesículas extracelulares por protozoários parasitas
• Beneficiário: Sergio Schenkman
• Modalidade de apoio: Auxílio à Pesquisa - Regular