| Texto completo | |
| Autor(es): Mostrar menos - |
Martini, Tatiana
;
Rios, Daniela
;
Dionizio, Aline
;
Silva Cassiano, Luiza de Paula
;
de Souza E Silva, Cintia Maria
;
Taira, Even Akemi
;
Oliveira Ventura, Talita Mendes
;
Frazao Camara, Joao Victor
;
Araujo, Tamara Teodoro
;
Magalhaes, Ana Carolina
;
Carvalho, Thiago Saads
;
Baumann, Tommy
;
Lussi, Adrian
;
de Oliveira, Ricardo Brandt
;
Palma-Dibb, Regina Guenka
;
Rabelo Buzalaf, Marilia Afonso
Número total de Autores: 16
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BRAZILIAN ORAL RESEARCH; v. 37, p. 16-pg., 2023-01-01. |
| Resumo | |
The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW). Twenty-four volunteers were divided into 3 groups: 1) GERD and ETW; 2) GERD without ETW; and 3) control (without GERD). The AEP formed 120 min after prophylaxis was collected from the lingual/palatal surfaces. The samples were subjected to mass spectrometry (nLC-ESI-MS/MS) and label-free quantification by Protein Lynx Global Service software. A total of 213 proteins were identified, or 119, 92 and 106 from each group, respectively. Group 2 showed a high number of phosphorylated and calciumbinding proteins. Twenty-three proteins were found in all the groups, including 14-3-3 protein zeta/delta and 1-phosphatidylinositol. Several intracellular proteins that join saliva after the exfoliation of oral mucosa cells might have the potential to bind hydroxyapatite, or participate in forming supramolecular aggregates that bind to precursor proteins in the AEP. Proteins might play a central role in protecting the dental surface against acid dissolution. (AU) | |
| Processo FAPESP: | 17/17977-8 - Proteoma da película adquirida e saliva em voluntários com refluxo gastresofágico com erosão dentária ou não e avaliação in vitro do potencial protetor da hemoglobina contra a erosão dentária |
| Beneficiário: | Tatiana Martini |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/12041-7 - Segurança e eficácia para prevenção da erosão dentária de uma nova cistatina derivada da cana-de-açúcar (CaneCPI-5): estudos in vitro, in situ e in vivo |
| Beneficiário: | Marília Afonso Rabelo Buzalaf |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |