Correlation between periodontal disease, inflammatory alterations and pre-eclampsia

Autor(es)

Politano, G. T. ^[1] ; Passini, R. ^[2] ; Nomura, M. L. ^[2] ; Velloso, L. ^[3] ; Morari, J. ^[3] ; Couto, E. ^[2]

Afiliação do(s) autor(es)

^[1] Dent Sch Sao Leopoldo Mandic, Dept Pediat Dent, Campinas, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Dept Obstet & Gynecol, Campinas, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, Campinas, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PERIODONTAL RESEARCH; v. 46, n. 4, p. 505-511, AUG 2011.
• Citações Web of Science: 14

Resumo

Background and Objective: Several studies have hypothesized that periodontal disease may increase the risk of pre-eclampsia. The correlation between the two diseases would probably be based on hypertension-related cytokine release in the local periodontal environment. The aim of this study was to evaluate the association between periodontal disease and pre-eclampsia, and the correlation of the two conditions with interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha) mRNA expression. Material and Methods: A case-control analysis of 116 pregnant women, 58 with pre-eclampsia (cases) and 58 normotensive pregnant women (controls) was performed. In addition to collection of socio-demographic data and periodontal evaluation, peripheral blood samples were collected for laboratory analysis of IL-6 and TNF alpha mRNA expression by real-time PCR. Results: There was an association between periodontitis and pre-eclampsia (adjusted odds ratio 3.73; 95% confidence interval 1.32-10.58). Increased TNF alpha mRNA expression was observed in pre-eclamptic women; however, there was no correlation between periodontitis and systemic cytokine expression. In the case group, systemic cytokine mRNA levels were similar in pregnant women with and without periodontitis (means +/- SD): 0.73 +/- 0.24 vs. 0.82 +/- 0.38 for TNF alpha and 1.31 +/- 1.49 vs. 1.09 +/- 0.74 for IL-6, respectively. Conclusion: Periodontitis was clinically related to pre-eclampsia; however, the supposed mechanism that correlates the two diseases, i.e. a systemic inflammatory process involving cytokines TNF alpha and IL-6 in the presence of periodontal disease, could not be confirmed in this study. (AU)

• Processo FAPESP: 07/58124-6 - Doença periodontal como fator de risco para pré-eclâmpsia: estudo caso-controle
• Beneficiário: Anibal Eusébio Faúndes Latham
• Modalidade de apoio: Auxílio à Pesquisa - Regular