| Texto completo | |
| Autor(es): |
Almeida, L. F.
;
Gil, G. A.
;
Moraes, L. N.
;
Furtado, F. B.
;
Kakuda, L.
;
Grotto, R. M. T.
;
Oliveira, W. P.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Microencapsulation; v. 41, n. 4, p. 12-pg., 2024-04-30. |
| Resumo | |
This work aimed to investigate the effectiveness of Lippia sidoides and Syzygium aromaticum essential oils (EOs) encapsulated in nanostructured lipid carriers (NLCs) as SARS-CoV-2 inhibitors through virucidal activity assessment. We developed anionic and cationic NLCs loaded with the EOs and assessed their physicochemical properties and SARS-CoV-2 virucidal activity, focusing on the effects of EO type and the NLCs composition. The NLCs exhibited particle sizes of 141.30 to 160.53 nm for anionic and 109.30 to 138.60 nm for cationic types, with PDIs between 0.16 and 0.25. High zeta potentials (>29.0 in modulus) indicated stable formulations. The NLCs effectively encapsulated the EOs, achieving encapsulation efficiencies between 84.6 to 100% w/w of marker compound. The EOs-loaded NLCs reduced the SARS-CoV-2 virion count, exceeding 2 logs over the control. NLCs loaded with Lippia sidoides and Syzygium aromaticum EOs represent an innovative strategy for combating SARS-CoV-2. (AU) | |
| Processo FAPESP: | 16/20500-6 - Desenvolvimento e avaliação de meios filtrantes com nanofibras obtidos pelo processo de eletrofiação aplicados na filtração de gases |
| Beneficiário: | Mônica Lopes Aguiar |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/26069-0 - Encapsulação de óleos essenciais para uso em formulações farmacêuticas com atividade antimicrobiana |
| Beneficiário: | Wanderley Pereira Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |