| Texto completo | |
| Autor(es): |
Facco, Joao V.
;
Addas-Carvalho, Marcelo
;
Duarte, Adriana da Silva Santos
;
Zangirolami, Audrey B.
;
Benites, Bruno D.
;
Saad, Sara T. O.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Medical Virology; v. 96, n. 11, p. 6-pg., 2024-11-01. |
| Resumo | |
Studies have suggested an association between polymorphisms in class I genes of the major histocompatibility complex, specifically the human leukocyte antigen (HLA), and susceptibility to SARS-CoV-2. To explore this, 135 individuals with positive serological tests for SARS-CoV-2 were recruited. All the samples were collected before the advent of vaccines, avoiding immunization effects. Participants were divided into high and low neutralizing antibody titer groups, and polymorphisms in HLA-A, HLA-B, and HLA-DRB1 genes were examined using PCR-SSO. Allele prevalence in the study population was compared to the National Bone Marrow Volunteer Donors Register (REDOME) in S & atilde;o Paulo and between the high and low titer groups within the study population. Results indicated that the HLA-B*15 polymorphism was more prevalent in the COVID-19 positive group compared to the control population (COVID-19 = 0.1370; Control = 0.0875; p = 0.0067). The HLA-B*18 polymorphism was less prevalent in the COVID-19 group (COVID-19 = 0.0185; Control = 0.0534; p = 0.0064). Additionally, the HLA-A*30 polymorphism was more prevalent in the high titer group within the (high = 0.10937; low = 0.02816; p = 0.0125). Other polymorphisms showed no significant differences. These findings align with international studies, suggesting these genes plays a role in COVID-19 pathophysiology, however, further research is required to fully understand their impact. (AU) | |
| Processo FAPESP: | 17/21801-2 - Preditores de gravidade e novos tratamentos para neoplasias da medula óssea |
| Beneficiário: | Sara Teresinha Olalla Saad |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |