Pesticide-Induced Inflammation at a Glance

Autor(es)

Lopes-Ferreira, Monica ; Farinha, Luiz Rogerio Ludwig ; Costa, Yasmin Stefanie Oliveira ; Pinto, Felipe Justiniano ; Disner, Geonildo Rodrigo ; da Rosa, Joao Gabriel dos Santos ; Lima, Carla

• Tipo de documento: Artigo Científico
• Fonte: TOXICS; v. 11, n. 11, p. 15-pg., 2023-11-01.

Resumo

The increasing number of studies reporting the risks of the exposure to pesticides aligned with the intensified use of such hazardous chemicals has emerged as a pressing contemporary issue, notably due to the potential effects to both the environment and human health. Pesticides, while broadly applied in modern agriculture for pest control and crop protection, have raised concerns due to their unintended effects on non-target organisms. The immune system exerts a key role in the protection against the exposome, which could result in cellular imbalances and tissue damage through the inflammatory response. Pesticides, which encompass a diverse array of chemicals, have been linked to inflammation in experimental models. Therefore, the aim of this review is to discuss the increasing concern over the risks of pesticide exposure focusing on the effects of various chemical classes on inflammation by covering, as broadly as possible, different experimental approaches as well as the multiple or co-exposure of pesticides. Overall, pesticides potentially induce inflammation in different experimental models, manifested through skin irritation, respiratory impairment, or systemic effects. The connection between pesticides and inflammation highlights the importance of proper handling and regulation of these substances and underscores the need for research into safer and sustainable practices to reduce our reliance on synthetic pesticides and fertilizers. (AU)

• Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
• Beneficiário: Hugo Aguirre Armelin
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 21/08891-8 - Avaliação dos mecanismos farmacológicos do peptídeo TnP isolado do veneno de Thalassophryne nattereri na terapêutica da Retinopatia Hipóxica em Zebrafish
• Beneficiário: João Gabriel dos Santos da Rosa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/06084-8 - Avaliação da importância funcional de proteínas da família Natterin na ativação do inflamassoma em zebrafish
• Beneficiário: Carla Lima da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/27677-7 - Estudo da indução de microRNAs regulatórios por TNP dependente da ativação do receptor de hidrocarboneto arílico (AhR)
• Beneficiário: Geonildo Rodrigo Disner
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado