| Texto completo | |
| Autor(es): Mostrar menos - |
Gennari, J. D'Agostino
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Deveza, G. B. H.
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Ribeiro, C. T.
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Seguro, A. C.
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Aikawa, N. E.
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Shimizu, M. H. M.
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Leon, E. Pires
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Guedes, L. K. N.
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Kupa, L. V. K.
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Silva, C. A. A.
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Bonfa, E.
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Pasoto, S. G.
Número total de Autores: 12
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| Tipo de documento: | Artigo Científico |
| Fonte: | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; v. 42, n. 12, p. 10-pg., 2024-12-01. |
| Resumo | |
Objective<br /> N-acetylcysteine (NAC) is used in Sjogren's disease (SjD) based on limited evidence. The aim of this study was to assess the efficacy of NAC for relieving dryness symptoms in SjD. Methods<br /> In this placebo-controlled double-blind trial, 60 adult SjD females (with low disease activity) were randomised to receive NAC (1,200 mg/day orally) or placebo. At baseline (D0), 30 days (D30) and 90 days (D90), all participants underwent the following evaluations: EULAR Sjogrens' Syndrome Patient Reported Index (ESSPRI), Ocular Surface Disease Index (OSDI), Xerostomia Inventory (XI), Leicester Cough Questionnaire (LCQ), unstimulated/stimulated salivary flow, Schirmer's test, and plasma levels of thiobarbituric acid reactive substances (TBARS), glutathione and NAC. Results<br /> At inclusion, both groups were balanced for age, ethnicity, disease duration, ESSPRI, OSDI, XI, Schirmers' test, salivary flow, ESSDAI and topical/systemic treatments (p>0.05). No significant differences were observed between NAC and placebo groups on D30 and D90 regarding ESSPRI, XI, OSDI, LCQ, Schirmer's test, stimulated salivary flow, ESSDAI and topical/systemic treatments (p>0.05). Unstimulated salivary flow was significantly higher in the placebo group on D90 (p=0.018). NAC blood concentrations were significantly higher in the NAC group on D30 (p=0.018) and D90 (p<0.001), however, no differences were found in TBARS and glutathione. Further analysis showed a decrease >= 1 in ESSPRI in the NAC compared with placebo group on D30 (p=0.045), a result not found on D90 (p=0.696).<br /> Conclusion<br /> NAC is recommended as a rescue therapy for SjD. However, our well-designed study provides novel evidence demonstrating its inefficacy for improving dryness symptoms or reducing oxidative stress. Clinicaltrials.gov-NCT04793646. (AU) | |
| Processo FAPESP: | 19/17272-0 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica |
| Beneficiário: | Leonard de Vinci Kanda Kupa |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 15/03756-4 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica |
| Beneficiário: | Eloisa Silva Dutra de Oliveira Bonfá |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/21173-7 - Avaliação do tratamento do lúpus eritematoso cutâneo com talidomida: fatores clínicos, laboratoriais e histológicos associados à resposta clínica e efeitos adversos |
| Beneficiário: | Carolina Torres Ribeiro |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 20/11677-5 - Análise do perfil imune da saliva e soro dos pacientes com Síndrome de Sjögren Primária |
| Beneficiário: | Giordano Bruno Henriques Deveza |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |