| Texto completo | |
| Autor(es): |
Gomes Cabral, Tadeu Luiz
;
Dal Poggetto, Guilherme
;
Brussolo da Silva, Joo Pedro
;
Nilsson, Mathias
;
Tormena, Claudio F.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | LANCET GASTROENTEROLOGY & HEPATOLOGY; v. 10, n. 2, p. 6-pg., 2025-02-01. |
| Resumo | |
Enantiomers are ubiquitous in many areas of science, such as pharmaceuticals, agriculture, and food. Nuclear magnetic resonance (NMR) alone is not able to differentiate enantiomers as their spectra are identical. However, these can be distinguished using chiral auxiliaries (such as chiral complexing agents) that form diastereomeric complexes, but absolute identification is still troublesome, usually requiring a chemical reaction with a chiral derivatizing agent. Here, we propose a new method that uses a hybrid mixture of solvating agents in a simple comparison of diffusion NMR experiments, which can discriminate enantiomers in both frequency and diffusion domains, dubbed CHIMERA (CHIral Micelle Enantiomer Resolving Agent). The new method was assessed for twenty-three small chiral molecules using a combination of BINOL and (-)-DMEB, a chiral surfactant, and initial results indicate that absolute configuration can be obtained from a simple experiment. (AU) | |
| Processo FAPESP: | 21/05081-5 - Micelas quirais para DOSY assistida por matriz |
| Beneficiário: | Tadeu Luiz Gomes Cabral |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 20/10246-0 - Ressonância magnética nuclear: das sequências de pulso a determinação estrutural |
| Beneficiário: | Claudio Francisco Tormena |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |