Autor(es)

de Lima, Fernando Freitas ; Mendonca, Talita Cesarim ; Pinilla, Cristian Mauricio Barreto ; Alvim, Izabela Dutra ; Vido, Mariana Alves Gragnani ; de Paula, Eneida ; Spadoti, Leila Maria ; Silva e Alves, Adriana Torres

• Tipo de documento: Artigo Científico
• Fonte: FOOD BIOSCIENCE; v. 62, p. 9-pg., 2024-09-14.

Resumo

In this study, (3-carotene ((3C) was encapsulated in liposomes and spray-dried with the probiotic bacteria Lactobacillus rhamnosus GG (LGG), to obtain a biphasic structure with two functional components. Initially, the liposomes loaded with (3C resulted in large multivesicular vesicles (LMVV) with spherical morphology, mean size of 1191 nm and entrapment efficiency of 81.33%. Then, the spray-drying of the mixture (3C-LMVV with the LGG resulted in biphasic dried microparticles (BDM) with a spherical shape, retention of 64,48% of (3C, and LGG survivor above 90%. The BDM showed high storage stability for 90 days at room temperature and, at the dose of 2000 mg/kg of BDM did not cause any acute toxicity in Wistar rats. In addition, at the same dose, presented significant anti-inflammatory activity in carrageenan-induced paw edema and pleurisy. Thus, the produced BDM could be an innovative ingredient with functional properties and also an efficient encapsulation strategy for (3C. (AU)

• Processo FAPESP: 21/04987-0 - Produção de biomassa de bactérias ácido láticas autóctones em meios a base de diferentes tipos de soro de leite e otimização de processos de secagem
• Beneficiário: Cristian Mauricio Barreto Pinilla
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/12121-0 - Desenvolvimento de uma formulação de liberação sustentada para tetracaína em lipossomas com gradiente iônico
• Beneficiário: Fernando Freitas de Lima
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado