Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics

Autor(es)

Villabona-Arenas, Christian Julian ^[1] ; de Andrade Zanotto, Paolo Marinho ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Lab Mol Evolut & Bioinformat, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INFECTION GENETICS AND EVOLUTION; v. 11, n. 5, p. 878-885, JUL 2011.
• Citações Web of Science: 24

Resumo

Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 08/10713-6 - Estudo das proteínas estruturais e a caracterização da proteina codificada pela ORF-31 do Nucleopoliedrovírus Anticarsia gemmatalis (AgMNPV-2D) em linhagens de células de inseto distintas
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular